Abstract
Pore forming molecules of the cholesterol-dependent cytolysin family are expressed by various Gram-positive bacteria. The family member pneumolysin (PLY) is a virulence factor associated with Streptococcus pneumoniae (Spn) and forms pores in membranes. PLY contributes to host-mediated macrophage apoptosis, an event which is critical to the eventual resolution of the inflammatory response. We hypothesise that the host response to PLY triggers apoptosis and aim to identify the PLY activity responsible and characterise the specific host-pathogen interaction involving PLY.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
