Abstract
Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999–2000 to 3.8% and 4.2%, respectively, in 2010–2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008–2009 and 2010–2011. The only major serotype that increased from 2008–2009 to 2010–2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease.
Highlights
Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods
Infections caused by Streptococcus pneumoniae include meningitis, pneumonia, bacteremia, bronchitis, sinusitis, and otitis media
The percentage of serotype 19A isolates increased from 2% in 1999–2000 to 22% in 2008–2009 (p
Summary
Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. The only major serotype that increased from 2008–2009 to 2010–2011 was nonvaccine serotype 35B These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease. A 30% decrease in the incidence of pneumococcal meningitis in the United States from 1998–1999 through 2004–2005 was attributed to direct vaccine effect and herd immunity, but the percentage of cases caused by non-PCV7 serotype strains, 19A, increased (7,8). Isolation of S. pneumoniae from a normally sterile site is always considered a pathogen, recovery from a respiratory site may represent colonization Despite these limitations, the role of surveillance that is not limited to isolates causing invasive disease is shown by recent studies reporting high case-fatality rates for noninvasive serotypes (15–17)
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