PND84 FACTORS THAT IMPACT HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH TARDIVE DYSKINESIA: REGRESSION ANALYSES OF DATA FROM THE REAL-WORLD RE-KINECT STUDY

Abstract

RE-KINECT, an ongoing study of tardive dyskinesia (TD) in antipsychotic-treated outpatients, includes 2 cohorts: patients with visible uncontrollable movements that are clinician-confirmed as possible TD (C2); and patients with no visible movements or with non-TD movements (C1). Data from the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) questionnaire, administered before cohort assignment, were analyzed to assess health-related quality of life (HRQoL) in C2 vs. C1 and the effects of possible TD on HRQoL (C2 only). To eliminate non-TD as a confounding factor, patients who presented with (or reported having) any uncontrollable movements not confirmed as TD were excluded from C1. A linear regression model (adjusted for confounding factors: age, gender, overall health, psychiatric severity, functional status, psychiatric diagnosis) was used to analyze the difference in EQ-5D-5L utility score (0=health state equivalent to death; 1=perfect health) between C2 (n=204) and C1 (n=450). Analyses were also conducted based on C2 patients who rated themselves as having “a lot” of overall TD severity (n=53) or “a lot” of TD impact on daily activities (n=41). In C2, the effects of TD severity (patient-rated, clinician-rated) and TD impact (patient-rated) on EQ-5D-5L utility were analyzed. The difference (±SE) between C2 and C1 was significant for EQ-5D-5L utility (-0.04±0.02, P<0.05). Larger significant differences were found when the model was limited to C2 patients with “a lot” of TD severity (-0.09±0.03; P<0.001) or TD impact (-0.15±0.03, P<0.001). EQ-5D-5L utility was most strongly associated with patient-rated TD impact (-0.021, P<0.001), followed by patient-rated TD severity (-0.028, P<0.05]). No significant association was found between EQ-5D-5L utility and clinician-rated TD severity (-0.007, P>0.05), which was significantly lower (less severe) than patient-rated severity (difference±SE: -0.28±0.12, P<0.05). TD is associated with measurably worse HRQoL, especially from the perspective of patients versus clinicians and particularly in patients who self-reported greater TD severity/TD impact.