PND4 - CLOBAZAM AS INTERMITENT PROPHYLAXIS IN TYPICAL FEBRILE SEIZURES AND THEIR ANEMIC STATUS

Abstract

To observe incidence of febrile seizures in Pediatric department from October to March 2018. To assess the cause of fever and identify risk factors in subjects with febrile seizures To assess the anemic status in the subjects and history of worm infestations and evaluating the reason for being anemic by using Kuppuswamy scale. To determine the adverse effects with clobazam. To assess the medication adherence status and improving the anemic status of subjects with febrile seizures by providing patient counselling. A descriptive cross-sectional observational study conducted in Government General Hospital, Guntur, a 1187 bedded tertiary care teaching hospital. Patients were randomly assigned to receive oral clobazam for 3 days with the following dosage: 5mg daily in children <5kg; 5mg, twice daily(BD) in children 6-10 kg; 7.5mg BD in children 11-15 kg ; 10mg BD in children >15kg. During the study period, incidence of febrile seizures in pediatric ward GGH was n=188 (5.38%) out of n=3495 children admitted and it was more in the month of December n=30 (6.50%).The mean Haemoglobin value before patient couselling was 7.98±1.35 gms and after counselling was 8.53±1.25 gms with a p value (0.001). The mean value of medication adherance before patient counselling was 3.78±1.61 and after counselling was 5.42±1.50 with a p value (0.001).The major risk factors observed were family history and anemia with a p value of (0.003).There was no recurrence of seizures in 114 subjects after Clobazam therapy as intermittent prophylaxis. The most commonly observed side effect was Sedation n=26 (21.12%) . This study concluded that Clobazam was effective as intermittent prophylaxis in preventing the recurrence of febrile seizures where anemia was a major risk factor and counselling plays a significant role in improving the anaemic status and adherence of the subjects.