PND112 REAL WORLD HEALTH UTILITY SCORES OF PATIENTS WITH ACUTE ISCHEMIC STROKE MEASURED USING EQ-5D-3L IN CHINA

Abstract

To obtain health utility scores (HUS) to estimate quality of life of Chinese patients with acute ischemic stroke (AIS) and provide data for cost-effectiveness analysis in the AIS area. A prospective phase IV multicenter clinical registry study was conducted in 79 hospitals since 2015. Chinese Patients with AIS were recruited and followed up for 1 year. They were required to complete questionnaires including demographic characteristics, NIH Stroke Scale (NIHSS), Glasgow Coma Scale (GCS), Modified Rankin Scale (mRS), and EQ-5D-3L. 8008 patients were included in the final analysis. The HUSs were 0.542 on the day of admission (0th day), 0.703 on the day of discharge, 0.795 on the 90th day and 0.844 on the 360th day. The HUSs were 0.564 for male and 0.500 for female. The HUSs were 0.572, 0.577, 0.543, 0.523 and 0.462 for the patients below 50 year-old, 50-59 year-old patients, 60-69 year-old patients, 70-79 year-old patients and patients over 80 year-old, respectively. Moreover, the HUSs were significantly different between patients with first-episode AIS and AIS recurrence (0.554 vs. 0.505). According to NHISS scores, the HUSs were 0.826 for normal group (NHISS score 0-1), 0.679 for mild group (2-4), 0.355 for moderate group (5-15), 0.062 for severe group (16-20) and -0.012 for very severe group (21-42). According to mRS levels, the HUSs were 0.901 for the 0th level, 0.821 for the 1st level, 0.624 for the 2nd level, 0.506 for the 3rd level, 0.232 for the 4th level and 0.029 for the 5th level. According to GCS scores, the HUSs were 0.607 for normal group (GCS score 15), 0.397 for mild group (12-14), 0.128 for moderate group (9-11) and 0.019 for severe group (3-8). This study obtained comprehensive HUS among Chinese patients with AIS. The HUS was significantly correlated with gender, disease recurrence and severity of disease.