PMON154 Cardiovascular Complications in Acromegaly-A National Inpatient Sample Analysis

Abstract

Abstract Introduction Cardiovascular complications are the frequent cause of death in Acromegaly. Most of the prior studies on the epidemiology of cardiovascular complications in Acromegaly had a small sample size due to the rarity of Acromegaly. We wanted to investigate the prevalence of cardiovascular risk factors and cardiovascular diseases in patients with Acromegaly in a large sample size using the NIS (National inpatient sample) Methods We utilized the National inpatient sample (NIS) 2016, 2017, and 2018 for our analysis. All patients with Acromegaly were included. The frequency of different cardiovascular risk factors and cardiovascular diseases was estimated. Results A total of weighted 5654 weighted hospitalizations (95% CI 5220-6089) with Acromegaly were included. Out of these, 15% had heart failure, 20% had cardiac arrhythmias, 7% had valvular diseases, 3% had pulmonary circulation disorders, 6.9% had peripheral vascular diseases. 42.1% had hypertension with no complications, 13.9% had hypertension with complications, 2% had paralysis, 17.7% had Diabetes mellitus without complications, 15.2% had Diabetes mellitus with complications, 20.9% had obesity, 33% had dyslipidemia, 11.6% had nicotine dependence, and 4.7% had a family history of myocardial infarction. The mean elixhauser comorbidity score was 2.9. A total of 33% of patients had pituitary surgery at the time of hospitalization. Discussion Cardiovascular risk factors and cardiovascular diseases remain a significant issue in acromegaly patients. Hypertension was the most common cardiovascular risk factor, and cardiac arrhythmias were the most common cardiovascular disease. Acromegaly patients have a higher risk for mortality than the general population due to cardiovascular complications. This is directly correlated with increased IGF-1 levels which can be eliminated with surgery. However, 80-90% of patients do not cure despite surgery. Hence, aggressive control of the cardiovascular risk factors and strict biochemical control is necessary to reduce cardiovascular mortality in acromegaly patients. Acromegaly patients should be regularly screened for cardiovascular risk factors, and they should receive guideline-directed management of these conditions. Potential limitations of our study include the retrospective nature, lack of documentation of pituitary resection, and the exact treatment received in the outpatient for Acromegaly in NIS. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.