PMO-249 Quantitative proteomic analysis of intermediate filament profile in ulcerative colitis reveals increased levels of keratins 8, 18 and 19 in patients with longstanding pan colitis which are reduced with development of dysplasia

Abstract

IntroductionIntermediate filaments (IF), principally keratins (K), are key components of epithelial cytoskeleton. K8, 18 and 19 are expressed in intestinal epithelial cells and play a role in cell-death signalling pathways,...