PMH33 The Use of High-Dose Statin Is Associated with a Reduced Risk of ALL-Cause Dementia

Abstract

The goal of this study was to analyze the association between the LDL cholesterol values and all-cause dementia as well as the impact of the statin therapy on the all-cause dementia in primary care outpatients in Germany. This retrospective case-control study included patients aged ≥65 years with an initial diagnosis of dementia in 963 general practices with documented LDL cholesterol in Germany between January 2015 and December 2019 (index date). The dementia cases were individually matched (1:1) to non-dementia controls by age group, gender, index year, and relevant comorbidities. The main outcome of the study was to examine the distribution of LDL cholesterol in the study population and to assess an association between high LDL cholesterol and the incidence of dementia. Logistic regression models were conducted to study the association between LDL cholesterol and dementia incidence. The present study included 12,236 patients with and 12,236 patients without all-cause dementia. There was no significant association between LDL values and the risk of all-cause dementia (Odds Ratio (OR: 0.99 (95% CI: 0.89-1.10) for LDL 70-99 mg/dl, OR: 1.02 (95% CI: 0.92-1.14) for LDL 100-129 mg/dl, OR: 1.03 (95% CI: 0.93-1.14) for LDL ≥ 130 mg/dl as compared to LDL <70. No significant associations were also observed for the risk of vascular dementia. However, a negative association between the use of high dosage statins and all-cause dementia (OR: 0.87 (95% CI: 0.78-0.97) for high statin versus no statin) was found. Although no association between LDL values and dementia was seen, the use of high dose statins was associated with a significantly lower dementia risk. Further studies are warranted to corroborate or invalidate these findings in other settings as well as to identify potential associated factors not assessed in this study.