Abstract
Oxidative stress and excessive lipid accumulation in liver tissues are considered as important factors in development of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and strongly associated with insulin resistance, obesity and dyslipidemia. In this study, the effect of PMFs-enriched extract of Daoxianyeju (Citrus daoxianensis S.W. He) (EDX) on NAFLD were examined using high fat diet-induced obesity (DIO) C57BL/6 mice. Daily supplementation of 0.2% and 0.5% EDX with high fat diet (w/w) over ten weeks markedly improved glucose tolerance and insulin resistance as well as lipid profiles, alleviated hepatic steatosis, inflammatory and oxidative stress. The benefit of EDX on improving pathology of NAFLD induced by high fat diet may associate with the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathways in liver tissues. Our study showed that citrus PMFs may use as a dietary therapy for NAFLD and related metabolic disorders.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
