Abstract
To investigate the diagnostic value (sensitivity, specificity, and accuracy) of non-invasive method of H. pylori (HP) stool antigen detection (rapid stool-test) at the primary diagnosis of HP infection, and in assessing the eradication therapy effectiveness. The study was conducted in 64 patients with gastroduodenal diseases, with complaints of epigastric pain and dyspeptic symptoms. The average age of patients was 42,8 ± 1,7, women - 38 (59.3%), men - 26 (40.7%). All patients underwent simultaneous determination of HP by histology and rapid-stool test and respiratory Helic-test (HT). Patients with the positive result according histological test was assigned eradication therapy. In 4 weeks after eradication patients were again tested for HP. For this purpose, the rapid-stool test and HT were conducted simultaneously. The rapid stool-test is the optimal non-invasive method of HP infection detection before and after the eradication therapy, as Its sensitivity - 83%, specificity - 82% and accuracy - 83%. HT results are: 72%, 66%, 70% respectively. In order to assess the significant differences in the two groups (stool-test and HT) we carried out correlation analysis by Pearson x2. x2= 0.046, which is less than the critical 3.841, hence the significance of differences in the two groups is absent. Correlation analysis showed that for the detection of HP diagnostic properties of rapid stool-test and HT quite high and quite comparable to each other (x2 = 0.046, p> 0.05). The effectiveness of the eradication assessed by the rapid stool-test was 81%, and by HT - 58% (x2 = 3.250, p> 0.05), which confirmed its high diagnostic value in monitoring the effectiveness of eradication therapy. Non-invasive and highly informative express stool-test of HP antigen detection with monoclonal antibodies allowed to substantiate its diagnostic value, and therefore, to implement it for the HP infection diagnosis and dynamic observation in outpatient.
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