Abstract
MICA antibody identification is a test performed on transplant patients to check for the presence of donor-specific MICA for the purpose of predicting the incidence of organ rejection among transplant patients. The purpose of this assessment was to evaluate the effectiveness. The literature search was performed using 8domestic research databases and 3core databases. A total of 9papers that remained. Each of the stages from literature search to application of selection criteria and data extraction was independently by 2researcher. The SIGN was used for the quality assessment. There were 5studies reporting on the medical results of kidney transplant patients. 2of the studies reported no significant differences in the graft survival rate and incidence of organ rejection(p=.67). However, 3studies reported a low graft survival rate and a significantly lower incidence of organ rejection in MICA(-)patients compared to the MICA (+)patients. There were 3studies reporting of heart transplant patients. 2studies reported an incidence of organ rejection of 23.1~62.5% and 1study reported a 5~10year graft survival rate of 94.7%(p=ns). There was one study reporting of lung transplant patients. The incidence of organ rejection was reported to be 42.0%(p=ns). MICA Identification lacked clinical effectiveness for the following reasons: i)there were no significant differences in the graft survival rate and incidence of organ rejection; ii)it is difficult to determine whether the different results for the graft survival rate and incidence of organ rejection reported; iii)the results cannot be generalized as it is probable that they will change in case of including all the patients fitting the description; iv)kidney transplantation is presently performed even if the results of the histocompatibility test of the donor and the patient do not conform to each other; v)heart and lung transplantations are performed based on anatomical compatibility without a histocompatibility test.
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