PM299 Influence Of Aging And Gender In Cardiac Function And Structure By Using Speckle-Tracking Echocardiography

Abstract

Introduction: CHD is the leading cause of mortality and morbidity in men as well as in women. Men and women share the same coronary risk factors but ischemic heart disease appears later in women than in men although this diference reduces and disappears in older age group. Whereas, the cardiovascular death rates are declining in men,they remain constant in women. However, it remains unclear whether this higher mortality is explained by the higher age of females or presence of other risk factors, notably diabetes. Objectives: To assess any gender differences on treatment and clinical outcomes in patients with AMI in Durres population. Methods: 362 patients consecutive with acute myocardial infarction (AMI) who presented in the Cardiology Department, Regional Hospital of Durres, Albania between January 2011 to January 2013 were included in the study. The patient characteristics, treatment, and hospital outcome were collected and validated. In-hospital management and outcomes were compared between men and women. Results: Of 362 pts, 129(35.63%) were women and 233 (64.37%) were men. Mean age in men was 61.08 1.41 and mean age in women was 69.97+8.59.(8 years older than men) p< 0,001. Women had a higher incidence of diabetes and hypertension(52.7.% vs.43.7%,p < 0.001 and 64.3% vs.47.7%, p <0.001) and were more obese (59.1% vs38.8% p < 0.001). Smoking and family risk factor were found in men more than in women (61.5% vs. 21.1%, p < 0.001 and 33.8% vs.26.4%,p < 0.001). Cardiac dispnea and shock were more frequently in women than men (47.3% vs40.6%). There was no difference in the treatment with Bblocker, statine, ACEI, and ARB aspirin, clopidrogel, enoxaparine. No gender diferences in coronary angiografy e PCI (70.6% vs 70.8%) p 0.963. Unadjusted inhospital mortality was significantly higher in women than in men (22.4% vs.12.7%). Conclusion: Women with AMI were older and had a higher incidence of hypertension, obesity and diabetes than men. Women had a higher risk for in-hospital morbidity and mortality than men. No association was observed between the gender of patients with AMI and the application of diagnostic or therapeutic procedures. Disclosure of Interest: None Declared