Abstract
O ST E R A B ST R A C Results: Age (r 1⁄4 -0.128, P 1⁄4 0.02), female sex (r 1⁄4 0.106, P 1⁄4 0.05), weight to length z-score at birth (r 1⁄4 0.085, P 1⁄4 0.12), primigravida status (r 1⁄4 -0.084, P 1⁄4 0.13) and maternal body mass index (r 1⁄4 -0.106, P 1⁄4 0.09) were most strongly associated with telomere length in univariate analysis (P > 0.25 for all other comparisons). In multivariable modeling, significant independent predictors of longer telomere length in early childhood were younger age (-0.117 units per year [95% CI -0.210, -0.024], P 1⁄4 0.01), female sex (0.199 units [95% CI 0.016, 0.382], P 1⁄4 0.03), and lesser maternal BMI (-0.013 units per kg/m [95% CI -0.025, -0.000], P 1⁄4 0.05). Conclusion: Age, male sex and maternal adiposity are independently associated with telomere shortening in early childhood. Disclosure of Interest: None Declared T S
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