Abstract
Knowledge of the biological response to inhaled plutonium in animals is necessary in order to understand the changes that might occur in man accidently exposed during the industrial and military handling of this fissionable material. Acute effects were observed in earlier investigations of inhaled (1, 2) and intratracheally injected (3) Pu23902. A deposited dose of 1 Asc/kg caused lymphopenia, respiratory distress, loss of body weight, and finally death within 2 to 4 months postexposure (1). This study was designed to define more clearly the acute syndrome resulting from a single high-level inhalation exposure to plutonium dioxide aerosol. Particular attention was given to the progressive clinicopathologic changes occurring in the exposed animals and their correlation with the tissue changes observed at necropsy. Radiochemical analyses of all urine, feces, and body tissues provided the basis for determining total plutonium deposited and retained, and the amount translocated.
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