Abstract
Forty-eight beagle dogs were exposed to plutonium dioxide aerosols of three particle size distributions. The aerosol concentrations varied from 0.1 to 1000 picocuries per cc air and the total plutonium deposited varied from 0.01 to 100 mu c. For a given amount of plutonium deposited the percentage apparently deposited in the alveoli and retained for gradual clearance was greatest for plutonium inhaled as particles with a mass median diameter of 4.3 mu , less for 3.3 mu , and even less for 0.65 mu particles. The rate of clearance, translocation, and excretion in urine and feces was greatest for plutonium inhaled as particles with a mass median diameter of 0.65 mu . Possible explanations for the results are discussed and the importance of the results to health physics practices is indicated. (anth)
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