Abstract
Colon cancer ranks as the third most common malignancy in the world. Combination chemotherapy, resorting to electrospun fibrous technology, has been considered as a promising strategy to exert synergistic effects in colon cancer treatment. Herein, we manufactured various pluronic F127 (PF127)-modified electrospun fibrous meshes with different weight ratios of camptothecin (CPT) and curcumin (CUR). The fluorescence characterization of the obtained PF127-CPT-meshes, PF127-CUR-meshes, and PF127-CPT/CUR-meshes (2:1) showed that CPT and CUR were evenly distributed within individual fibers of these meshes. Drug release experiments revealed that both types of drugs could be released from fibrous meshes simultaneously and sustainably. Importantly, these meshes exhibited strong in vitro anti-colon cancer activities, compared with the control meshes without drugs. Moreover, the combination index values of the PF127-CPT/CUR-meshes (CPT/CUR weight ratio = 5:1, 3:1, or 2:1) were <0.5 after incubation for respective 24 and 36 h, indicating the synergistic anti-colon cancer effects of CPT and CUR in fibrous meshes. Collectively, these results demonstrate that PF127-CPT/CUR-meshes can be developed as an efficient implantable system for effective synergistic treatment of colon cancer.
Highlights
Colon cancer is one of the most common malignancies around the world, which is associated with high morbidity and mortality (The Colon Cancer Laparoscopic or Open Resection Study Group, 2009; Arnold et al, 2017)
It was obvious that the blank pluronic F127 (PF127)-mesh exhibited no fluorescence signals
In terms of PF127CPT/CUR-mesh (2:1), both blue and green fluorescence signals were detected from its fibers
Summary
Colon cancer is one of the most common malignancies around the world, which is associated with high morbidity and mortality (The Colon Cancer Laparoscopic or Open Resection Study Group, 2009; Arnold et al, 2017). Drug delivery systems (DDSs) such as liposomes, hydrogels, and fibrous meshes have been exploited as feasible platforms for controlled drug release, maximized therapeutic efficacy, and minimized side effects (Wiranowska et al, 2019) Among these DDSs, electrospun fibrous meshes appear as one of the most versatile and scalable DDSs for localized chemotherapy. The electrospinning technique has the advantages of being mild and relatively straightforward (Mirjalili and Zohoori, 2016; Ma et al, 2019) Characterized by their large specific surface area, electrospun fibrous mesh has been considered as a multi-faceted and malleable DDS, which has the superiority of transformation to suitable shapes and specific sizes catering to the post-resection space of tumor sites, balance of the weight ratios of the loaded drugs, and reservation of their anti-cancer activities (Xie et al, 2010). Their in vitro synergistic anti-cancer activities were evaluated
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
