Abstract
This mini-review highlights the latest advances in the chemistry and biology of Pluronic® triblock copolymers. We focus on their applications in medicine, as drug delivery carriers, biological response modifiers, and pharmaceutical ingredients. Examples of drug delivery systems and formulations currently in clinical use, clinical trials or preclinical development are highlighted. We also discuss the role that Pluronic® copolymers may play in the innovative design of new nanomedicines in the near future.
Highlights
The design and fabrication of nanosized objects by using nanotechnology tools have recently resulted in a number of conceptual advances, and directly impact other elds, such as neuroscience, medicine, and energy.[1,2,3,4] The last decades have seen the emergence of new nanomaterials and the development of safer and more effective medicines opening up new perspectives for addressing social and environmental critical issues.[5]
We focus on their applications in medicine, as drug delivery carriers, biological response modifiers, and pharmaceutical ingredients
It is clear that the utilisation of nanotechnology tools for the design of polymer nanoparticles, being still an emergent concept, has already shown tangible promise in medicine
Summary
Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances Cite this: Polym. This mini-review highlights the latest advances in the chemistry and biology of Pluronic® triblock copolymers. We focus on their applications in medicine, as drug delivery carriers, biological response modifiers, and pharmaceutical ingredients. Examples of drug delivery systems and formulations currently in clinical use, clinical trials or preclinical development are highlighted. We discuss the role that Pluronic® copolymers may play in the innovative design of new nanomedicines in the near future
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