Abstract
In the top right image the simulated methylation patterns in a nonhierarchical (classical) malignancy, indicated with different colors, radiate outward from the center. In the bottom left image, in contrast, the patterns occurring in a hierarchical (CSC-driven) tumor spread as patch-like colonies, increasing the overall intratumor heterogeneity and greatly affecting the evolutionary properties of the cancer cell population. (See Sottoriva et al., doi: 10.1371/journal.pcbi.1001132) Image Credit: Andrea Sottoriva, Cambridge University, United Kingdom
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
