Abstract
During embryonic development, growing spinal projections establish complex neural networks with their peripheral targets. For proper limb innervation, motor and sensory axons converge in the brachial plexus to form spinal nerves. Wholemount staining of a mouse E10.5 embryo captures the growing sensory (red, neurofilament staining) and motor axons (green, Hb9::eGFP) in the brachial plexus of the forelimb. The study by Huettl et al. (e1001020) demonstrates that removal of the axon guidance receptor Neuropilin-1 from sensory neurons (Npn-1cond -/-;Ht-Pa-Cre+) results in breaking of the tight coupling between sensory and motor axons and defasciculation of sensory and, surprisingly, motor trajectories. Image Credit: Rosa-Eva Huettl.
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