Abstract
Nanoparticle has a wide range of advantages to protect active pharmaceutical ingredient, targeted medicine as well as control release rate in the drug delivery system. PLGA is biodegradable high polymer and commonly-used in biomedical tissue engineering by the mole ratio adjustment between lactic acid and glycolic acid in order to control high polymer ability. Rapamycin clinically inhibit immunological reaction and cure anti-inflammatory as well as inhibit cancer cells mitotic that will reach anti-cancer effect. This experiment will be focused on including Rapamycin into PLGA and making PLGA into multi-layer fibroin and synthesized thin films. Then, with the ratio adjustment between fibroin and synthesized thin film, we will make controlled drug release ratio. With solvent evaporation method, we analyze how to make particles and what the particle size and shape like by electron microscope with 10cm diameter. We examine the medication package of 43.4% from UV spectrometers and the accumulated drug release rate can reach at 98.61% in thirty days. With the mixed ratio of fibroin and synthesized thin films in the particles for 1:1ヽ2:1ヽ4:1, the total accumulated release rate will be 84.9%ヽ74.7%ヽ67.4% individually. This package method can release Rapamycin slowly but effectively that will improve drug burst phenomenon.
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