Abstract
PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.
Highlights
Heart disease is one of the primary threats to human health
A Poly lactic-co-glycolic acid (PLGA) drug-loading coating was prepared using electrostatic spray deposition (ESD) with 316 L stainless steel as the support for coatings, PLGA 75/25 as the carrier, and RAPA as the drug; the surface morphology, degradation characteristics, and blood compatibility of the coating were investigated in order to provide a theoretical basis for the study of drug-loading coating stent
The drug-loading coating was subjected to the following preparation procedures: (i) The 316 L medical stainless-steel sample (Φ10 mm × 2 mm) was successively placed in acetone, ethanol, and distilled water for ultrasonic cleaning for 20 min after polishing, and dried in a vacuum oven at 80 ◦C for 24 h. (ii) PLGA75/25 was dissolved in 1,4-dioxane to prepare a uniform solution, and RAPA was dissolved in that solution to prepare the paint. (iii) The stainless-steel substrate was grounded into electrical neutral through a conductor
Summary
Heart disease is one of the primary threats to human health. Currently, approximately one million patients worldwide receive percutaneous coronary angioplasty (PTCA) every year [1]. Electrostatic spray deposition (ESD) uses high pressure to crack the polymer solution into fine droplets that adsorb to the substrate surface using a strong electric field to obtain uniform and smooth coatings. This method sees broad utilization in machinery, chemical industry, electronic information, micro medical devices, medical information, and others [13,14,15]. A PLGA drug-loading coating was prepared using ESD with 316 L stainless steel as the support for coatings, PLGA 75/25 as the carrier, and RAPA as the drug; the surface morphology, degradation characteristics, and blood compatibility of the coating were investigated in order to provide a theoretical basis for the study of drug-loading coating stent. The charged coating adsorbed to the stainless-steel surface and formed a uniform coating via the combination of electric field gravity and high-voltage thrust
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