Abstract
Schwannoma is a benign peripheral nerve sheath tumor that mostly affects young adults. It commonly affects cutaneous tissues of the head and neck region and is classified into four histopathological variants: conventional, cellular, plexiform, and melanotic. Young woman, 14, presented a nodular lesion in the hard palate of normal color that measured 3.0 cm. Pleomorphic adenoma was suspected. The incisional biopsy specimen revealed multiple round nodules demarcated with a fibrous capsule. The nodules mainly consisted of Antoni A tissue with spindle-shaped cells arranged in a nuclear palisade, along with well-developed Verocay bodies. Areas of Antoni B tissue were less frequently seen. Microscopic analysis was compatible with plexiform schwannoma (PS). Immunohistochemical analysis showed positive reactions for S-100 protein and vimentin in hypercellular and hypocellular areas. PS is extremely rare in the oral cavity. Peripheral nerve tumors are subject to frequent misdiagnosis, often mimicking neoplasms of different prognosis and treatment.
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