Abstract
The present work was aimed to screen the antibacterial, anticancer and mosquito-larvicidal potentials of the titanium dioxide mediated nanoparticles (TiO2NPs) from the Pleurotus sajor caju fruiting bodies. The synthesized TiO2NPs were characterized using UV–Vis spectrum, FTIR, XRD, FESEM, EDX, HRTEM, Zeta potential and Particle size analyses. The XRD pattern show pure crystalline nature of the TiO2NPs and spherical shape morphology was noted. The average size of nanoparticles was 85 nm and Zeta potential analysis, resulted the surface charge of the nanomaterial was − 8.05 mV. The larvicidal activity of TiO2NPs treated IVth instar larvae of Aedes aegypti and Culex quinquefasciatus showed better LC50 and LC90 values (14.56, 26.56 and 12.76, 24.38 mg/l). The broad spectrum of antibacterial activity was observed both gram-positive and gram-negative bacteria and maximum growth inhibition zone was recorded in Klebsiella pneumoniae (8.0 ± 0.3 mm) followed by other tested organisms. The anticancer activity [bone cancer (MG-63) cell line] of TiO2NPs expressed best IC50 value as 61.34 µg/ml, which conferred the cytotoxic effects of TiO2NPs on the proliferation of MG-63 cell line. Based on the findings of present study the biosynthesized TiO2NPs from P. sajor caju served as an alternative and eco-friendly nano medicine in the near future.
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