Abstract
EBV-positive diffuse large B-cell lymphoma of the elderly is a newly described aggressive lymphoma predominantly affecting patients >50 years of age. Patients may present with nodal and/or extranodal involvement. The lung is one of the more common extranodal sites. The incidence of pleural fluid involvement is less well described. In one study by Oyama et al., pleural effusions were noted in nine percent of cases. Identification of pleural fluid involvement could be important as it may carry prognostic importance in staging (it typically occurs more often in cases with widespread disease), and it could be a relatively easy means of establishing a diagnosis in newly presenting cases. We report the first description of the pleural fluid cytology in a case of EBV-positive diffuse large B-cell lymphoma of the elderly.
Highlights
EBV-positive diffuse large cell lymphoma (EBV+ DLBCL) of the elderly is a newly recognized aggressive B-cell lymphoproliferative disorder
While pleural effusions have been noted in these patients, the cytologic features have not been described
Identification of pleural fluid involvement may provide a rapid diagnosis as well as assist in staging the tumor. This is the first description of the cytologic features of pleural fluid involved by EBV+ DLBCL of the elderly
Summary
EBV-positive diffuse large cell lymphoma (EBV+ DLBCL) of the elderly is a newly recognized aggressive B-cell lymphoproliferative disorder. Unlike other EBV-associated lymphomas, EBV+ DLBCL of the elderly occurs exclusively in patients with no history of immunodeficiency. While pleural effusions have been noted in these patients, the cytologic features have not been described. This is the first description of the cytologic features of pleural fluid involved by EBV+ DLBCL of the elderly.
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