Abstract

Question: A 59-year-old man with medical history of end-stage renal disease, liver cirrhosis, and hepatocellular carcinoma had undergone liver transplantation. After liver transplantation, he had regular use of oral-form tacrolimus of 2 mg/d. Four months after liver transplantation, hepatitis was detected at the outpatient department. For suspicions of transplant rejection, the dosage of tacrolimus was titrated to 4 mg/d. One month later, he presented to the hospital with a 5-day history of exertional dyspnea and orthopnea.

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