Abstract
Background: Pleomorphic adenomas are benign salivary gland tumors predominantly arising from the superficial lobe of the parotid gland and rarely from the small salivary glands located at various locations including parotid, lacrimal duct, lip, floor of the mouth etc. Surgical excision of the tumor mass is the treatment of choice with utmost care taken to preserve the facial nerve in cases involving the parotid gland. Case details: This case series highlights three consecutive cases of pleomorphic adenoma arising from three different locations. Conclusion: Pleomorphic adenoma is the commonest salivary gland tumor characterized by diverse histomorphological features and can occur at any site where salivary tissue is present. Careful histopathological analysis should be done in all tumors arising especially in the head and neck region.
Highlights
Pleomorphic adenoma (PA), known as benign mixed tumor, is the most common type among benign tumors of salivary glands and majority of them arise in the parotid gland followed by the submandibular gland
10% of the PAs originate from the small salivary glands, and can develop at any site where these glands are located, including the palate, upper lip, floor of the mouth, lacrimal gland, larynx, and trachea[1-3]
In this case series we report three consecutive cases of pleomorphic adenoma diagnosed at our hospital, each arising at a different location
Summary
Pleomorphic adenoma (PA), known as benign mixed tumor, is the most common type among benign tumors of salivary glands and majority of them arise in the parotid gland followed by the submandibular gland. 10% of the PAs originate from the small salivary glands, and can develop at any site where these glands are located, including the palate, upper lip, floor of the mouth, lacrimal gland, larynx, and trachea[1-3] In this case series we report three consecutive cases of pleomorphic adenoma diagnosed at our hospital, each arising at a different location. Histopathology revealed an encapsulated tumor showing a few ductal epithelial cells and abundant plasmacytoid cells in sheets amidst a chondromyxoid stroma (Figure 1). Histopathological examination revealed normal salivary gland in the periphery with an encapsulated tumor composed of epithelial and myoepithelial cells in a myxomatous stroma (Figure 2). The patient was referred for a FNAC and cytology showed a cellular smear with plenty of myoepithelial cells in sheets with abundant fibrillary myxoid background. The tumor was diagnosed as a case of pleomorphic adenoma and the patient is on regular follow up
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