Abstract
Plenary Sessions
Highlights
Recent models on metastatic invasion focus on the tumor-”host”interface, in particular the role of the stromal tissue
Our results suggest that pretherapeutical gene expression profiling may assist in response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy and in prediction of disease free survival if validated in larger independent studies
Our findings demonstrate the overall maintenance of a radial gene-density correlated chromatin arrangement in tumor cell nuclei irrespective of chromosomal arrangements observed in the different cell types
Summary
Recent models on metastatic invasion focus on the tumor-”host”interface, in particular the role of the stromal tissue. Cancer is a genetic and epigenetic disease that results from lesions affecting genes, microRNA and pathways whose dysregulated expression causes the constellation of growth, differentiation and cell death alterations leading to tumor development.
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