PLEN02 Presentation Time: 1:30 PM: Association of Brachytherapy Boost with Overall Survival in Men with Gleason Grade Group 5 Prostate Cancer Treated with Radiation and Androgen Deprivation Therapy

Abstract

Purpose: Men with Gleason grade group 5 (GG5) prostate cancer (PCa) have particularly aggressive disease, and current guidelines recommend external beam radiation therapy (EBRT) with or without a brachytherapy (BT) boost plus androgen deprivation therapy (ADT) or radical prostatectomy (RP) with pelvic lymph node dissection. The largest retrospective cohort study to date previously demonstrated that EBRT plus a BT boost was associated with significantly better prostate-cancer specific mortality (PCSM) and lower rate of distant metastases (DM) compared with EBRT alone (Kishan, JAMA 2018).