Abstract
Amiodarone was developed in the early 1960s based on extracts from the Khella plant and was initially used as a coronary dilator for the treatment of angina pectoris (Singh 2008). In 1970, Singh and Vaughan Williams discovered that amiodarone also directly affected myocardial tissue, prolonging the cardiac action potential and protecting against ouabain-induced arrhythmias in guinea pigs (Singh and Vaughan Williams 1970). To date, amiodarone remains one of the most commonly prescribed antiarrhythmic drugs in clinicalpracticeandisusedinthetreatmentofbothventricular
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