Pleiotropic action of genetic variation rs1344706 in ZNF804A on brain structure and function in patients with schizophrenia

Abstract

Objective To explore the association between the ZNF804A gene genetic variation polymorphism rs1344706 and brain structure and function in patients with schizophrenia. Methods Literature search was conducted in Pubmed and other databases, the processes were performed in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, then the Comprehensive Meta-Analysis software was used for meta-analysis. Results Schizophrenia patients with rs1344706 risk allele had lager gray matter in the amount of brain regions including frontal lobe (z=3.445, P=0.001), temporal lobe (z=2.140, P=0.032) and other brain regions; healthy controls with the risk allele had smaller gray matter and regional activity in the frontal lobe (gray matter: z=-2.008, P=0.045, regional activity: z=-4.036, P<0.01) and other regions. Sensitivity analysis was stable, but publication bias existed in a few analyses of indexes. Conclusion The risk allele in ZNF804A gene rs1344706 has positive effects on the brain structure in patients with schizophrenia, but negative effects on the brain structure and function in the healthy individuals. Key words: Zinc finger protein 804A; Brain structure and function; Schizophrenia; Meta analysis