Plecanatide, Nusinersen, and Obeticholic acid

Abstract

Individuals who experience persistent constipation (i.e., for more than 6 months) for which there is no apparent explanation (e.g., obstruction, use of medications such as opioids) are diagnosed as having chronic idiopathic constipation (CIC). CIC is experienced more often by women than men, and more often in those older than 65 years of age, and it does not typically respond to standard treatment such as the use of laxatives. Medications with a labeled indication for CIC include lubiprostone (Amitiza) and linaclotide (Linzess). Daniel A. Hussar, PhD, Remington Professor of Pharmacy, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA Deborah K. Douglas, Student Pharmacist, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA