Abstract
Osteoarthritis (OA), the most prevalent articular disease with the clinical syndrome of joint pain accompanied by varying degrees of functional limitation, reduces the quality of elderly life. In this study, the effects of Plebeian sage extract (PS) on anti-inflammatory and anti-articular cartilage degradation activities were evaluated in rats with surgically induced OA. PS supplement for 12 weeks significantly decreased Mankin scores, including inflammatory cell numbers, and improved surface cartilage damage and mean femur and tibia articular cartilage (AC) thicknesses in OA rats. PS diminished IL-1β, IL-6, TNF-α, MMP-2, MMP-3, and MMP-9, as well as lipocalin-2 levels in serum or cartilage, which were increased due to OA. The results suggested that PS decreased joint inflammation and loss of articular cartilage by suppressing provocative responses and synovial tissue decimation in the OA model. Thus, PS may be used as a novel potential therapeutic regime for OA in the elderly.
Highlights
Flavanone (1) derivatives were tentatively identified from the leaf and Plebeian sage extract (PS) through positive ionized mass fragmentation using UPLC-diode array detector (DAD)-QToF/MS analysis (Table 3)
We found that PS decreased serum matrix metalloproteinases (MMPs)-2, MMP-7, MMP-9, MMP-13, and lipocalin-2 levels when administered at a dose of 100 or 300 mg/kg (p < 0.05) compared with those of the negative control (NC) group
The present investigation demonstrates that PS significantly improved surface cartilage damage, Mankin scores, mean femur and tibia articular cartilage (AC) thicknesses, and inflammatory cell numbers in rats with surgically induced OA
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Osteoarthritis (OA) is the most prevalent articular disease in the elderly [1]. The process is characterized by changes in the structure and function of the articulation, mainly due to a degenerative process that takes place in the articular cartilage [2,3]. OA is the most common clinical syndrome of joint pain accompanied by varying degrees of functional limitation that reduces the quality of elderly life [4]. Subchondral bone remodeling and a meniscal damage occur in OA, which is a whole joint disorder, affecting all joint tissues that communicate at the cellular level by releasing and responding to inflammatory mediators
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