Abstract
A new unusual minor triterpenoid saponin, platycoside O (1), was isolated from the 75% EtOH extract obtained from the roots of Platycodon grandiflorum, together with four known saponins: platycoside M-3 (2), platycoside J (3), platycoside F (4) and platycoside B (5). The structure of 1 was determined as 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-24-methoxyl, 24-oxo-28-oic acid 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside on the basis of spectral analysis and chemical evidence.
Highlights
Platycodon grandiflorum (Campanulaceae) is a species of perennial flowering plant of the familyCampanulaceae and the only member of the genus Platycodon
Chemical investigation of P. radix revealed that triterpenoid saponins were the main chemical components [1], which exhibit a variety of pharmacological activities, such as anti-inflammatory [2,3], protective effects on the hepatotoxicity induced by chemicals [4,5], anti-antioxidant [6], anti-cancer [7,8]
We reported the isolation and structural elucidation of eleven new triterpenoid saponins, including several unusual A-ring lactone triterpenoid saponins, from the roots of
Summary
Platycodon grandiflorum (Campanulaceae) is a species of perennial flowering plant of the family. More than 40 triterpenoid saponins have been isolated from the roots of the plant [1,11,12,13,14,15,16,17,18,19,20,21]. Further investigation on the polar fractions of P. grandiflorum led to the isolation from the EtOH extract obtained from the roots of a new unusual minor triterpenoid saponin based on the sapogenin platycogenic acid A, named platycoside O, together with four known compounds. To the best of our knowledge, the triterpenoid saponins based on the sapogenin platycogenic acid A had been isolated only in the plant and reported in a few publications [19,22]
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