Abstract
Parkinson’s disease is a common progressive neurodegenerative disorder associated with inflammation. Platycodin D (PLD) is a triterpenesaponin that has anti-inflammatory and neuro-protective effects. However, the role of PLD in Parkinson’s disease has not been fully investigated. In the current study, we investigated the effect of PLD on 1-methyl-4-phenylpyridinium (MPP+)-induced inflammatory response in BV-2 cells. Our results showed that PLD treatment improved the cell viability of MPP+-induced BV-2 cells. PLD significantly inhibited the levels of inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in MPP+-treated BV-2 cells. The increased productions of inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and IL-6 in MPP+-treated BV-2 cells were also suppressed by PLD. Furthermore, PLD inhibited the activation of TLR4/MyD88/NF-κB pathway in MPP+-treated BV-2 cells. Overexpression of TLR4 reversed the protective effects of PLD on MPP+-treated BV-2 cells. Collectively, PLD protected BV-2 cells from MPP+-induced inflammatory response via regulating the TLR4–MyD88–NF-κB signaling pathway.
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