Abstract
BackgroundNew nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT.ResultsLight microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively.ConclusionsPtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy.
Highlights
New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought
Morphology and structure of PtAu NRs The morphology and the chemistry of PtAu NRs were studied by electron microscopy
A larger magnification Scanning transmission electron microscopy (STEM) image of the Pt nanoparticle, Fig. 1a, reveals that it consists of < 5 nm small platinum nanoparticles (Pt NPs), which agglomerated into a spherical object
Summary
New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. The main reason, are unique properties of nanoparticles when compared with bulk materials [1]. The scale decrease significantly modifies structural, optical, mechanical and electrical properties of these materials. Nanoparticles, having sizes similar to biomolecules, can pass through the cell lipid bilayer, offering the opportunity to use NPs in biological systems [2]. Nanoparticles are used as imaging agents, drug delivery systems or radiosensitizers in proton, radiation and photothermal therapy (PTT) [3,4,5]. In PTT, nanoparticles are delivered to the tumor cells and subsequently exposed to light at the NPs resonant energy, causing synchronized oscillation of the NPs conduction-band
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