Abstract
AbstractA wide range of simple organic substrates has been successfully tritium labelled using reduced platinum oxide as catalyst. Exchange conditions involved reaction temperatures in the range 60–150°C, and reaction times of 3–7 days. The isotope sources for the reactions were tritium gas and tritiated water. Analysis of the labelled products was accomplished by radio‐glc and by 3H NMR spectroscopy. The specific activities ranged up to 1100 mCi/mL, and most of the labelled products showed high radiochemical purity. The regioselectivity of tritium incorporation, as obtained from 3H NMR studies, supports currently accepted theories for mechanisms of platinum‐catalyzed hydrogen isotope exchange. The results also show remarkable consistency for a heterogeneous system under widely varying reaction conditions.
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