Abstract
Some platinum (IV) complexes [Pt(L) 2Cl 2] [where, L = 2-aminopyridine- N-thiohydrazide (L 1), (2-aminopyridine- N-thio)-1,3-propanediamine (L 2), benzaldehyde-2-aminopyridine- N-thiohydrazone (L 3) and salicylaldehyde-2-aminopyrtidine- N-thiohydrazone (L 4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione–thiol tautomer and coordinate as a bidentate N–S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes.
Published Version
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