Abstract
Adduct formation by aromatic ring stacking and electrostatic interactions has been investigated for solutions containing platinum DNA intercalators Pt(L)(en) 2+ (L=2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), 5-nitro-1,10-phenanthroline (nphen), 3,4,7,8-tetramethyl-1,10-phenanthroline (Me 4 phen); en=ethylenediamine) and mononucleotides NMP 2− (=AMP, GMP, CMP, UMP) or adenosine by spectroscopic methods. Difference absorption spectra of the Pt(L)(en) 2+ -NMP 2− systems revealed spectral changes in the region 290-350 nm probably due to the stacking interaction between Pt(L)(en) 2+ and NMP 2− , which was supported by the induced circular dichroism (CD) peaks observed in this region. The stacking has been substantiated by 1 H NMR spectra
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