Abstract
There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.
Highlights
Platinum-based compounds have been widely used in cancer chemotherapy
For drugs commonly used in platinum-based chemotherapy, many specific side effects may occur in the treated patient, such as cardiotoxicity, nephrotoxicity, ototoxicity, hematological toxicity, hepatotoxicity, gastrointestinal toxicity, and neurotoxicity
Similar chemical and physical properties of platinum and palladium suggest that they can be used interchangeably in analogous compounds of antitumor properties [12]. Both metals belong to the same group in the periodic table—platinum-group elements (PGE) and the bonds formed by them have similar lengths
Summary
Platinum-based compounds have been widely used in cancer chemotherapy. The primary compound that led to the development of this group is cisplatin. Inhibition of cell proliferation without a corresponding inhibition of bacterial growth was observed due to the reaction of platinum from the electrodes with NH4Cl, resulting in the formation of cisplatin, which was the cause of these changes [2] Rosenberg and his partners began experimenting on mice with leukemia and sarcoma [3], which led to the start of clinical trials in 1971. Similar chemical and physical properties of platinum and palladium suggest that they can be used interchangeably in analogous compounds of antitumor properties [12] Both metals belong to the same group in the periodic table—platinum-group elements (PGE) and the bonds formed by them have similar lengths. Because of the complexity of the issue, we have attempted to organize the existing data
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