Abstract
Objective:Preterm premature rupture of membranes (PPROM) is closely related with maternal and fetal complications. Therefore, early diagnosis is extremely important to provide maternal and fetal well-being. Many inflammatory markers have been evaluated for their ability to diagnose membrane rupture at early stages. We aimed to investigate the relationship between the platelet-to-lymphocyte ratio (PLR) and preterm premature membrane rupture.Material and Methods:In this study, 121 pregnant women with PPROM and 96 age-matched pregnant women with spontaneous preterm labor who were admitted to our hospital between January 2014 and December 2015 were enrolled. Demographic data, complete blood cell count results, and neonatal outcomes were recorded.Results:The neutrophil and platelet counts were higher in the PPROM group (9948.4±3393.2 vs. 7466.1±1698.5/mm3 and 244.5±60 vs. 210.6±64.8/mm3, respectively, p<0.001). The PLR and neutrophil-to-lymphocyte ratios (NLR) were both significantly higher in the PPROM group (p<0.001). Correlation analysis revealed that the PLR was positively correlated with the NLR (r=0.10, p=0.031). The ability of the PLR to diagnose preterm premature rupture of membranes was evaluated using an ROC curve. The sensitivity and specificity of the PLR was 57.8% and 73.7%, respectively, at a threshold >117.14 (p<0.001).Conclusion:The PLR might be a cost effective, easy to use, and practical marker for the early diagnosis of PPROM, which can help to determine the appropriate waiting time for delivery and provide maternal and fetal well-being.
Highlights
Preterm premature rupture of membranes (PPROM), which is defined as spontaneous rupture of fetal membranes before labor begins before 37 weeks’ gestation, affects approximately 3% of all pregnancies [1]
neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) were both higher in the PPROM group (p
With the exception of sepsis, a similar relation was found between the two groups according to the neonatal outcomes of pregnancies; sepsis was more common in the PPROM group [3]
Summary
Preterm premature rupture of membranes (PPROM), which is defined as spontaneous rupture of fetal membranes before labor begins before 37 weeks’ gestation, affects approximately 3% of all pregnancies [1]. It is closely related with significant maternal and fetal morbidity and mortality. The risk of chorioamnionitis is approximately 6-10% and increases to 40% if it prolongs over 24 hours [4]. Neonatal infection risk is two times greater in patients without chorioamnionitis [5]. Infection risk increases with PPROM, and neonatal hypoxia
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