Abstract
Platelets contribute to processes beyond thrombus formation and may play a so far underestimated role as an immune cell in various circumstances. This review outlines immune functions of platelets in host defense, but also how they may contribute to mechanisms of infectious diseases. A particular emphasis is placed on the interaction of platelets with other immune cells. Furthermore, this article outlines the features of atherosclerosis as an inflammatory vascular disease highlighting the role of platelet crosstalk with cellular and soluble factors involved in atheroprogression. Understanding, how platelets influence these processes of vascular remodeling will shed light on their role for tissue homeostasis beyond intravascular thrombosis. Finally, translational implications of platelet-mediated inflammation in atherosclerosis are discussed.
Highlights
The vasculature is one of the large networks of the human body and, it needs to be well protected by immune mechanisms
During thrombus formation, other systems located within the vasculature can be activated, the most prominent of which is the immune system and inflammation being a part of its innate response
And in close proximity, platelets are recruited to the wound to restore endothelial integrity; they are activated and initiate thrombus formation
Summary
Reviewed by: Marco Emilio Bianchi, Universita’ Vita Salute San Raffaele, Italy Gaurav K. Platelets contribute to processes beyond thrombus formation and may play a so far underestimated role as an immune cell in various circumstances. This review outlines immune functions of platelets in host defense, and how they may contribute to mechanisms of infectious diseases. A particular emphasis is placed on the interaction of platelets with other immune cells. This article outlines the features of atherosclerosis as an inflammatory vascular disease highlighting the role of platelet crosstalk with cellular and soluble factors involved in atheroprogression. Understanding, how platelets influence these processes of vascular remodeling will shed light on their role for tissue homeostasis beyond intravascular thrombosis. Translational implications of platelet-mediated inflammation in atherosclerosis are discussed
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