Abstract
BackgroundThe lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count. Our aim was to study the validity of platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) as simple tools to assess chronic lung disease severity or predict its course.ResultsIn 39 pediatric patients with CLD, we showed a significant rise in PLTs and PCT and a significant lower MPV when compared to normal controls (P values 0.003, 0.010, 0.004, respectively). Also, a significant positive correlation was detected between the C reactive protein (CRP) level and both the PLTs and PCT (r 0.327, 0.363 respectively) in addition to a significant reduction in MPV level in relation to the age of disease onset (P value 0.031).ConclusionThis study disagrees with the postulation that chronic lung disease could lead to the reduction of circulating platelets and emphasizes the role of increased platelets count and decreased MPV in reflecting the inflammatory condition underlying the chronic lung disease in the pediatric age group.
Highlights
The lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count
The current study revealed that pediatric patients with CLD had significantly higher platelet count when compared to the normal control group (P values 0.003), we showed a significant decrease in the mean platelet volume (MPV) among the patients group when compared to the normal control group (P values 0.004), the plateletcrit was significantly higher when compared to the normal group (P value 0.010)
MPV, and plateletcrit where studied among the CLD group and compared to different parameters including age, age of onset, oxygen saturation, hemoglobin concentration, total leucocytic count (TLC), Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), presence of fever, and changing pattern of chronic cough, sputum, or dyspnea
Summary
The lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count. Our aim was to study the validity of platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) as simple tools to assess chronic lung disease severity or predict its course. The murine model of chronic obstructive pulmonary disease (COPD) has shown that lungs may serve as a reservoir for megakaryocytes and hematopoietic progenitor cells, where almost half of the platelets may be produced [4]. This finding sheds new light on thrombopoiesis in. Previous studies demonstrated that blood leaving the lungs contained more platelets and fewer megakaryocytes than blood entering the lungs [8]
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