Abstract
Platelets are small (5-9 fl) blood cells, with discoid structure (1.5μm x 0.5-1μm), without nucleous. They are derived from megakaryocytes and enter in the circulation while being under the regulation of thrombopoeitin, a hormone produced mainly in the liver. Platelets are found in mammals, probably as an evaluating process after severe bleeding. They are constituted of many glycoprotein receptors and proteins (such as GPIb/IX/V, GPIb/IIa, GPVI, PAR1, PAR2, P2Y12, P-selectin), all of which are related to platelets adhesion and aggregation and of many platelet organelles as dense and a-granules which include substances related to clot formation, induction signaling of endothelial cells and control of haemostasis in general [1-4].
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