Abstract
Platelets are important actors of cardiovascular diseases (CVD). Current antiplatelet drugs that inhibit platelet aggregation have been shown to be effective in CVD treatment. However, the management of bleeding complications is still an issue in vascular diseases. While platelets can act individually, they interact with vascular cells and leukocytes at sites of vascular injury and inflammation. The main goal remains to better understand platelet mechanisms in thrombo-inflammatory diseases and provide new lines of safe treatments. Beyond their role in hemostasis and thrombosis, recent studies have reported the role of several aspects of platelet functions in CVD progression. In this review, we will provide a comprehensive overview of platelet mechanisms involved in several vascular diseases.
Highlights
Platelets are important actors of cardiovascular diseases (CVD)
The current use of antithrombotic drugs, aspirin, and P2Y12 antagonists, is based on their inhibitory effect on platelet aggregation. While those drugs show a beneficial effect in CVD, they are still associated with some bleeding risks
Recent studies provided a new understanding of the role of platelets in vascular inflammation that extends beyond their role in aggregation
Summary
Laboratory of Vascular Translational Science, U1148 Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Paris Cite, Univ Paris Diderot, Paris, France. The main goal remains to better understand platelet mechanisms in thrombo-inflammatory diseases and provide new lines of safe treatments. Beyond their role in hemostasis and thrombosis, recent studies have reported the role of several aspects of platelet functions in CVD progression. We will provide a comprehensive overview of platelet mechanisms involved in several vascular diseases. The current dogma is that arterial thrombi are composed of aggregated platelets and venous thrombi are enriched in fibrin This view has been challenged with landmark works by several groups on the role of platelets in venous thrombosis [3, 4]. We will provide a brief description of the role of platelets in clot formation and discuss their implication in vascular diseases
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