Abstract

Platelets are classically considered initiators of hemostasis and—in pathology—intravascular thrombosis causing diseases such as myocardial infarction or stroke. However, platelets are also mediators of innate immunity, secrete inflammatory proteins, mediate leukocyte recruitment, and contribute to tissue remodeling. Inflammation and innate immunity have common intersection points with the hemostatic system at various levels. With the complement system being part of the innate immune system, this chapter focuses on the role of platelets and the complement system in the context of atherosclerosis.

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