Abstract
Background: Chronic endometritis (CE) is one of aggressive factor of infertility and reproductive losses.
 Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) treatment of chronic endometritis (CE) treatment in women with infertility (PI) and recurrent pregnancy losses (RPL).
 Material and methods: In this non-randomized clinical trial, women aged 22-45 years with CE diagnosed by positive CD 138 between February 2017 and December 2019 were included. Were investigated 65 women - 30 patients with RPL and 35 women with PI and unsuccessful attempts at IVF. PRP therapy was performed paracervical ( 6 ml) and intrauterus ( 1,5 ml) once a week for 4 -8 weeks. Control of the treatment of CE was performed by endometrial biopsy pipelines 15-20 days after the last PRP.
 Results: After carrying out 4 procedures of combined paracervical and intrauterine PRP, CE was cured in 70-77% of women (p <0.05); after 8 procedures - 97% (p <0.01).
 Conclusions: Combined intrauterine and paracervical PRP therapy is an effective treatment for CE in women with PI and RPL.
Highlights
IntroductionThe influence of chronic endometritis (CE) as a factor of infertility and habitual miscarriage is actively discussed in the domestic and world literature [12], [18]
The use of platelet-enriched plasma (PRP) in spa conditions in recent years is gaining more and more popularity, in cosmetology, and in women with gynecological problems.The influence of chronic endometritis (CE) as a factor of infertility and habitual miscarriage is actively discussed in the domestic and world literature [12], [18]
After carrying out 4 procedures of combined paracervical and intrauterine PRP, CE was cured in 70-77% of women (p
Summary
The influence of chronic endometritis (CE) as a factor of infertility and habitual miscarriage is actively discussed in the domestic and world literature [12], [18]. The consequences of this pathology are the inability of women of reproductive age to implement reproductive plans, even after financially costly attempts at IVF, ICSI and donation programs [2], [24], [26]. Given the literature on the detection of CE in infertility (60-7290%) and pregnancy losses (64-76-86%), the diagnosis and treatment of this pathology are relevant [4], [6], [16]. Chronic endometritis (CE) is one of aggressive factor of infertility and reproductive losses
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