Abstract
Wound healing remained an equation with multiple variables that experts in the medical field are trying to solve. The need to find an adjuvant that can quicken the healing process is increasing with every day, as longer wound healing times raise the risk of infections. Platelet-rich plasma is a promising tool promoting faster healing in a variety of wounds (thermal wounds, burn wounds, surgeries, etc.), as a series of studies present encouraging results in patients that received platelet-rich plasma treatment. The aim of this paper is to review and comment on the useful benefits and limitations of using platelet-rich plasma as an adjuvant strategy in wound healing, emphasizing on skin related wounds.
Highlights
Skin tissue regeneration and a fast regeneration are important aspects in achieving a proper wound heal, in order to avoid the risk of infections, bad scarring or death
Wound healing naturally occurs after an injury and is an evolutionary conserved and complex process that requires an abundance of specific cells, growth factors and cytokines
platelet-rich plasma (PRP) is a plasma enriched with platelets that contain growth factors, that are considered to help with the processes of tissue regeneration and wound healing
Summary
Skin tissue regeneration and a fast regeneration are important aspects in achieving a proper wound heal, in order to avoid the risk of infections, bad scarring or death (in patients with pathologies that can affect the healing process). After an injury is inflicted, if the injured skin region fails to reepithelialize, this leads to infections, losing the barrier function of the organ and even death. This urges the need to a rapid wound closure by the proliferation of epithelial cells in order to restore the barrier function that is critically important for survival[2]. A plethora of studies claim and appraise the beneficial effects of platelet-rich plasma (PRP) on cellular proliferation and tissue regeneration on the ground that its molecular components, such as growth factors or cytokines, play an important role in these processes. The aim of this review is to highlight the benefits, efficacy and limitations of PRP use in wound healing
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