Platelet variation coefficient and its prognostic value in acute pancreatitis

Abstract

To evaluate the role of platelet variation coefficient in prediction of severity of acute pancreatitis (AP). The study included 90 patients with AP who admitted to the Tula City Emergency Hospital between 2018 and 2019. Patients had no signs of renal and hepatic insufficiency, cancer, blood diseases, inherited platelet disorders, previous splenectomy, antiplatelet and anticoagulant therapy. Mortality of patients with mild-to-moderate AP was 0%, severe pancreatic necrosis - 5.26%, extremely severe pancreatic necrosis - 92.3%. We analyzed the number and volume of platelets, thrombocytocrit and volume-adjusted distribution of platelets. All parameters were assessed after 1, 3, 7, 14, 21, 28 and 35 days. There was a significant correlation between AP severity and the number, volume and volume-adjusted distribution of platelets. Reduced platelet count, enlarged cells and heterogeneous volumes of platelets indicate severe course of pancreatitis. Identification of these changes as early as 3 days of disease is of great clinical importance. Platelet variation coefficient (PVC) is proposed to predict severity of AP. We found a direct correlation between IL-6 and PVC (correlation coefficient 0.78). The proposed PVC is available and easy to use for prediction of AP severity. It allows you to assess the course of acute destructive pancreatitis and effectiveness of treatment after the first three days of therapy. You can improve prediction of AP using this value.