Abstract
IntroductionThe lymphocytic population, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are prognostic tools predictive of adverse outcomes for several solid tumors and oncologic surgeries, one of which is esophageal adenocarcinoma. Furthermore, delayed resumption of oral feeding postoperatively is associated with significant morbidity. Given the controversies regarding post-op nutritional support in these patients, this study investigates the prognostic role of the lymphocytic percentage, the NLR, and the PLR in predicting prolonged length of hospital stay (LOHS) and ICU stay (LOICUS) as well as delayed oral feeding following transhiatal esophagectomy (THE) for adenocarcinoma of the esophagogastric junction (AEG).MethodsForty consecutive patients who underwent transhiatal esophagectomy performed by a single surgeon for Siewert type II and type III adenocarcinoma of the esophagogastric junction at a tertiary referral center were selected. Retrospective data collection was performed from the patients’ medical records, and statistical analysis was performed using Pearson correlation and Student’s t test and Chi-square testing.ResultsAn increased LOHS was correlated with a lower preoperative lymphocyte percentage (p = 0.043), higher NLR (p = 0.010) and PLR (p = 0.015), and an increased number of packed red blood cell (PRBC) transfusions perioperatively (p = 0.030). An increased LOICUS was correlated with a lower preoperative lymphocyte percentage (p = 0.033), higher NLR (p = 0.018) and PLR (p = 0.044), an increased number of PRBC transfusions (p = 0.001), and patients’ comorbidities (p < 0.05). A delay in feeding resumption was correlated with a lower preoperative lymphocyte percentage (p = 0.022), higher NLR (p = 0.004) and PLR (p = 0.001), an increased PRBC transfusions (p = 0.001), and diabetes mellitus (p = 0.033). Multivariate analysis with automatic linear modeling showed that only the preoperative PLR was a powerful predictor for the delay of feeding resumption (p < 0.01).ConclusionThe lymphocyte percentage, PLR, and NLR are found to be associated with prolonged hospitalization and ICU stay and delayed oral feeding following THE for Siewert types II and III AEG. We hope by this series, to have set, at least one preliminary cornerstone, in the creation of a prognostic model, capable of assessing the need for an intraoperative jejunostomy placement, in patients undergoing esophagectomy for distal esophageal carcinoma.
Highlights
The lymphocytic population, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are prognostic tools predictive of adverse outcomes for several solid tumors and oncologic surgeries, one of which is esophageal adenocarcinoma
Lymphocyte percentage, the neutrophil-tolymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR), which can be obtained from routine hematologic bloodwork, are markers of clinical and subclinical inflammation that have been both shown to be predictive of adverse perioperative outcomes in some studies and of no statistically significant utility in other studies [4, 6, 7]
Nine of these patients received neoadjuvant chemotherapy alone, and 3 patients received neoadjuvant chemotherapy and radiotherapy 1 month prior to surgery. None of these patients received any neoadjuvant treatment within 1 month of surgery in order to eliminate the influence of treatment on the preoperative complete blood count (CBC) and so the lymphocyte percentage, PLR, and NLR, as well as other preoperative labs [11]
Summary
The lymphocytic population, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are prognostic tools predictive of adverse outcomes for several solid tumors and oncologic surgeries, one of which is esophageal adenocarcinoma. Given the controversies regarding post-op nutritional support in these patients, this study investigates the prognostic role of the lymphocytic percentage, the NLR, and the PLR in predicting prolonged length of hospital stay (LOHS) and ICU stay (LOICUS) as well as delayed oral feeding following transhiatal esophagectomy (THE) for adenocarcinoma of the esophagogastric junction (AEG). Tumor-associated inflammation is an emerging field of interest and debate due to its implications on tumor progression and, subsequently, patient prognosis [3] The association between such factors and multiple solid tumors has been investigated, with numerous studies done on AEG [4,5,6,7]. Lymphocyte percentage, the neutrophil-tolymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR), which can be obtained from routine hematologic bloodwork, are markers of clinical and subclinical inflammation that have been both shown to be predictive of adverse perioperative outcomes in some studies and of no statistically significant utility in other studies [4, 6, 7]
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