Abstract
The in vivo platelet survival test, which is based on the rate of disappearance of labelled donor platelets from the circulation of the recipient, was evaluated as a means of assessing preimmunization to transplantation antigens. Platelet survival was shown to correlate closely with the intensity of immunization and proved to be most useful in predicting hyperacute rejection. The immunizing effect of test platelets was variable but slight and could be successfully prevented by 6-MP. The test appears to be more sensitive and accurate in predicting preimmunization than the lymphocyte cytotoxicity test.
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